abstract::EK1 peptide is a membrane fusion inhibitor with broad-spectrum activity against human coronaviruses (CoVs). In the outbreak of COVID-19, we generated a lipopeptide EK1V1 by modifying EK1 with cholesterol, which exhibited significantly improved antiviral activity. In this study, we surprisingly found that EK1V1 also di...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1917309
更新日期:2021-12-01 00:00:00
abstract::Intermolecular interaction between hPrP and αS was investigated using high-speed atomic force microscopy, dynamic light scattering, and nuclear magnetic resonance. We found that hPrP spontaneously gathered and naturally formed oligomers. Upon addition of monomer αS with a disordered conformation, poly-dispersive prope...
journal_title:Prionpub_type: 杂志文章
doi:10.1080/19336896.2021.1910176
更新日期:2021-12-01 00:00:00
abstract::Coronavirus disease 2019 (COVID-19) pandemic has brought unprecedented challenges to medical education systems and medical students. The aim of this study was to investigate the effects of COVID-19 pandemic on medical career and specialty choices among medical students. An online cross-sectional survey of Chinese medi...
journal_title:Medical education onlinepub_type: 杂志文章
doi:10.1080/10872981.2021.1913785
更新日期:2021-12-01 00:00:00
abstract::While DNA prime-protein boost vaccination approach has been widely used in preclinical and clinical studies especially in the field of HIV vaccine development, the exact role of DNA immunization has not been fully identified. Our previous work demonstrated that DNA immunization was able to elicit T follicular helper (...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1918026
更新日期:2021-12-01 00:00:00
abstract::In this study, a novel intelligent nanoplatform to integrate multiple imaging and therapeutic functions for targeted cancer theranostics. The nanoplatform, DOX@Gd-MFe3O4 NPs, was constructed Gd-doped mesoporous Fe3O4 nanoparticles following with the doxorubicin (DOX) loading in the mesopores of the NPs. The DOX@Gd-MFe...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1909177
更新日期:2021-12-01 00:00:00
abstract::The enzootic and zoonotic nature of H9N2 avian influenza viruses poses a persistent threat to the global poultry industry and public health. In particular, the emerging sublineage h9.4.2.5 of H9N2 viruses has drawn great attention. In this study, we determined the effects of the flexibility at residues 226 and 227 in ...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1919566
更新日期:2021-12-01 00:00:00
abstract::Seasonal affective disorder (SAD) is a type of depression in which symptoms occur during a particular season. While physical activity has been shown to improve symptoms for depression in general populations, the relationships between physical activity and experiences of seasonality and SAD remain underexplored. We con...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2021.1906058
更新日期:2021-12-01 00:00:00
abstract:AIM:MicroRNAs (miRNAs) are non-coding RNA molecules that serve as regulators following gene expression transcription. While studies have investigated the role of miRNAs in the pathogenesis of essential hypertension (HT), very few have considered their place in the pathogenesis of resistant hypertension (RH). The purpos...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1915800
更新日期:2021-12-01 00:00:00
abstract::Circular RNA hsa_circ_0000117 is reportedly increased in Gastric cancer (GC), however, its role is unexplored. Hsa_circ_0000117 expression and function in GC was investigated using standard cell phenotypic and expression assays. Pull-down and luciferase reporter assays also elucidated hsa_circ_0000117 mechanisms. In t...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1918992
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Dacomitinib and poziotinib, irreversible ErbB family blockers, are often used for treatment of non-small cell lung cancer (NSCLC) in the clinic. OBJECTIVE:This study investigates the effect of dacomitinib on the pharmacokinetics of poziotinib in rats. MATERIALS AND METHODS:Twelve Sprague-Dawley rats were rand...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1914114
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Healthcare complaints are an under utilised source of information for safety improvement, particularly in general practice settings. Within general practice in Ireland, complaints management is dependent on individual practice policies, with little standardisation nationally, impeding their use for safety im...
journal_title:The European journal of general practicepub_type: 杂志文章
doi:10.1080/13814788.2021.1900109
更新日期:2021-12-01 00:00:00
abstract::Processing method is considered as a major factor that affects biotransformation of phytochemicals in tea and leads to diverse flavor and bioactivity of tea. In the present work, six typical tea manufacturing processings were employed to compare the effect on chemical composition of teas through using leaves of the si...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1903237
更新日期:2021-12-01 00:00:00
abstract::RNA interference (RNAi) was used to investigate the role of epididymal vascular endothelial growth factor (VEGF) gene expression on sperm hyaluronidase (HYD) in a rat model of arsenic poisoning and to identify a new gene therapy target for male infertility caused by arsenic poisoning. The Rat model of chronic arsenic ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1915726
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Pectin is a plant heteropolysaccharide that is biocompatible and biodegradable, enabling it to be an excellent reducing agent (green synthesis) for metallic nanoparticles (MNPs). Nevertheless, in the biological industry, pectin has been left behind in synthesising MNPs, for no known reason. OBJECTIVE:To system...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1910716
更新日期:2021-12-01 00:00:00
abstract::Traumatic brain injury is a sudden trauma or blow on the head, and severe traumatic brain injury is a major cause of death and disability worldwide. The acute and chronic consequences following traumatic brain injury can lead to progressive secondary neurodegenerative changes and cognitive dysfunction. To date, there ...
journal_title:Neural regeneration researchpub_type: 杂志文章,评审
doi:10.4103/1673-5374.313014
更新日期:2021-12-01 00:00:00
abstract::In the peripheral nervous system, the activation of Sirtuin 1 can improve insulin resistance; however, the role played by Sirtuin 1 in the central nervous system remains unknown. In this study, rat models of diabetes mellitus were generated by a single injection of streptozotocin. At 8 weeks after streptozotocin injec...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.313051
更新日期:2021-12-01 00:00:00
abstract::Apoptosis, a key mechanism of programmed cell death, is triggered by caspase-3 protein and lowering its levels with gene therapy may rescue cell death after central nervous system damage. We developed a novel, non-viral gene therapy to block caspase-3 gene expression using small interfering RNA (siRNA) delivered by po...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.313068
更新日期:2021-12-01 00:00:00
abstract::Background: The new Family-Community-Hospital (FCH) three-level comprehensive management aimed to improve the efficiency and scale of peritoneal dialysis (PD) to meet the increased population of end-stage renal disease (ESRD). Our study focused on the clinical outcomes, quality of life, and costs evaluation of this mo...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1918164
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:In the migrant population, there is a higher risk of dementia. However, dementia is underdiagnosed in this population due to the underuse of appropriate screening tools. The Rowland Universal Dementia Assessment Scale (RUDAS) is designed for culturally and linguistically diverse populations. OBJECTIVES:To g...
journal_title:The European journal of general practicepub_type: 杂志文章
doi:10.1080/13814788.2021.1913116
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Paracetamol is recommended as first-line treatment for an acute sore throat. However, in primary care, antibiotics are still frequently prescribed as first-line management for sore throat. OBJECTIVES:We aimed to explore the views and experiences of general practitioners (GPs) and patients regarding paraceta...
journal_title:The European journal of general practicepub_type: 杂志文章
doi:10.1080/13814788.2021.1912730
更新日期:2021-12-01 00:00:00
abstract::Pediatric sepsis is a great threat to death worldwide. However, the pathogenesis has not been clearly understood until now in sepsis. This study identified differentially expressed mRNAs and lncRNAs based on Gene Expression Omnibus (GEO) database. And the weighted gene co-expression network analysis (WGCNA) was perfor...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1908029
更新日期:2021-12-01 00:00:00
abstract::As a malignant disease, lung cancer has a high morbidity and mortality rate. Baicalin is derived from Radix Scutellariae and has anti-tumor effects, however, its role in lung cancer remains unknown. Here, functional assays suggested baicalin suppressed in vitro lung cancer phenotypes. We used micro (mi)RNA array analy...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1922052
更新日期:2021-12-01 00:00:00
abstract::Mono-, di- and tri-methylation of histone H3 Lys 9, Lys 4, and Lys 36 (H3K_me1/me2/me3) required for mediation of DNA-based cellular events in eukaryotes usually rely upon the activities of histone lysine methyltransferases (KMTs) classified to the KMT1, KMT2, and KMT3 families, respectively. Here, an H3K9-specific DI...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1923232
更新日期:2021-12-01 00:00:00
abstract::There is a large, unmet medical need to treat chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis and other respiratory diseases. New modalities are being developed, including gene therapy which treats the disease at the DNA/RNA level. Despite recent innovations in non-viral gene therapy deliv...
journal_title:Journal of immunotoxicologypub_type: 杂志文章
doi:10.1080/1547691X.2021.1902432
更新日期:2021-12-01 00:00:00
abstract::Methionine/methionine type 1 (MM1-type) sporadic Creutzfeldt-Jakob disease (sCJD), known as the 'classic type,' shows typical clinicopathological sCJD findings. In general, patients reach an akinetic mutism state within a few months of disease onset and die soon after if supportive therapies are not administered. Here...
journal_title:Prionpub_type: 杂志文章
doi:10.1080/19336896.2020.1868931
更新日期:2021-12-01 00:00:00
abstract::Nociceptor sensitization following nerve injury or inflammation leads to chronic pain. An increase in the nociceptor hyperpolarization-activated current, Ih, is observed in many models of pathological pain. Pharmacological blockade of Ih prevents the mechanical and thermal hypersensitivity that occurs during pathologi...
journal_title:Channels (Austin, Tex.)pub_type: 杂志文章
doi:10.1080/19336950.2020.1870086
更新日期:2021-12-01 00:00:00
abstract::In chronic obstructive pulmonary disease (COPD) patients, bacterial and viral infections play a relevant role in worsening lung function and, therefore, favour disease progression. The inflammatory response to lung infections may become a specific indication of the bacterial and viral infections. We here review data o...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2020.1831050
更新日期:2021-12-01 00:00:00
abstract::The development of effective combined anti-retroviral therapy (cART) led to a significant reduction in the death rate associated with human immunodeficiency virus type 1 (HIV-1) infection. However, recent studies indicate that considerably more than 50% of all HIV-1 infected patients develop HIV-1-associated neurocogn...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2020.1814962
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Early diagnosis of head and neck cancer (HNC) will improve patient outcomes. The low incidence of HNC renders its detection challenging for a general practitioner (GP) in primary health care (PHC). PATIENTS AND METHODS:To examine these challenges, our cohort consisted of all patients visiting PHC centres in...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2020.1802060
更新日期:2021-12-01 00:00:00
abstract:INTRODUCTION:The activation of the sympathetic nervous system, which usually leads to a swift surge in blood pressure in the morning hours (MBPS) may be the cause of left ventricular hypertrophy (LVH) and endothelial dysfunction (ED) in early autosomal dominant polycystic kidney disease (ADPKD) patients. We studied the...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2020.1864403
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:In the first year of dialysis, patients are vulnerable to cardiovascular disease (CVD) hospitalization, but knowledge regarding the risk factors and long-term outcomes of cardiovascular readmission within the first year after dialysis in incident continuous ambulatory peritoneal dialysis (CAPD) patients is l...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2020.1866009
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Therapeutic benefits of immunotherapy are restricted by cancer immune-resistance mechanisms. Rediocide-A (Red-A), a natural product extracted from Traditional Chinese Medicine, is a promising agent to battle against cancer which acts as an immune checkpoint inhibitor. OBJECTIVE:To investigate the effect of Red...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2020.1865410
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Diabetes mellitus increases the risk of bone diseases including osteoporosis and osteoarthritis. We have previously demonstrated that Ficus deltoidea Jack (Moraceae) is capable of reducing hyperglycaemia. However, whether F. deltoidea could protect against diabetic osteoporosis remains to be determined. OBJECT...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2020.1865411
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Zataria multiflora Boiss (Lamiaceae) essential oil (ZME) is believed to be a bactericide herbal medicine and might alleviate negative effects of infection. OBJECTIVE:This study evaluates the effects of an ointment prepared from ZME (ZMEO) on infected wounds. MATERIALS AND METHODS:A full-thickness excisional s...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2020.1861029
更新日期:2021-12-01 00:00:00
abstract::In this study, we focused on readmissions for Ambulatory Care Sensitive Conditions (ACSC) ending in death, to capture those admissions and readmissions that might have been prevented if responsive primary healthcare was accessible. We propose this as a sentinel indicator of equity. We conducted analyses of Manitoba-ba...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2020.1859824
更新日期:2021-12-01 00:00:00
abstract::Staphylococcus aureus is one of the most frequent worldwide causes of morbidity and mortality due to an infectious agent. This pathogen can cause a wide variety of diseases, ranging from moderately severe skin infections to fatal pneumonia and sepsis. Treatment of S. aureus infections is complicated by antibiotic resi...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1878688
更新日期:2021-12-01 00:00:00
abstract::Direct contact between bone and implant materials is required for dental implants. Titanium is used for the implant material owing to its mechanical and biological properties. The anodisation as the surface treatment was employed to enhance osteogenesis around titanium. Moreover, carbon nanohorn (CNH), a type of nanom...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2020.1865388
更新日期:2021-12-01 00:00:00
abstract:PURPOSE:The purpose of this study is to explore experiences with daily challenges and the development of salutogenic copings skills among young adults with serious mental illness. METHODS:Nine young adults with serious mental illness were interviewed. The interviews were transcribed and subjected to reflexive thematic...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1879369
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVES:We aim to explore and analyze the related influencing factors of liver and cardiac iron overload in MDS patients detected by magnetic resonance imaging (MRI). METHODS:We have detected cardiac T2* and liver T2* by MRI in 105 MDS patients. Among them, 20 patients accepted MRI examination before and after iron...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2020.1866791
更新日期:2021-12-01 00:00:00
abstract::Atherosclerosis is a systemic disease associated with inflammatory cell infiltration and activation of immune-related pathways. In our study, we aimed to uncover immune-related changes and explore novel immunological features in the development of carotid atherosclerotic plaques. First, we applied integrated bioinform...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2021.1873798
更新日期:2021-12-01 00:00:00